abstract：:Although African swine fever virus (ASFV) replicates in viral cytoplasmic factories, the presence of viral DNA within the host cell nucleus has been previously reported to be essential for productive infection. Herein, we described, for the first time, the intranuclear distribution patterns of viral DNA replication ev...

journal_title：Virus research

authors： Simões M,Martins C,Ferreira F

更新日期：2015-12-02 00:00:00

abstract：:Fruit trees of temperate and tropical climates are of great economical importance worldwide and several viruses have been reported affecting their productivity and longevity. Fruit trees of different Brazilian regions displaying virus-like symptoms were evaluated for infection by circular DNA viruses. Seventy-four fru...

journal_title：Virus research

authors： Basso MF,da Silva JC,Fajardo TV,Fontes EP,Zerbini FM

更新日期：2015-12-02 00:00:00

abstract：:Viruses are strict intracellular pathogens that require the cellular environment to complete a successful infection. Among them, African swine fever virus (ASFV) is an evolutionary ancient DNA virus, endemic in Africa, which is nowadays causing an emergent disease in Europe with a potential high economic impact in the...

journal_title：Virus research

authors： Muñoz-Moreno R,Galindo I,Cuesta-Geijo MÁ,Barrado-Gil L,Alonso C

更新日期：2015-11-02 00:00:00

abstract：:Immunisation of goats, mice, rats, rabbits, guinea pigs, and hamsters with the recombinant ectodomain of the porcine endogenous retrovirus (PERV) transmembrane envelope (TM) protein (p15E) induced binding and neutralising immune antibodies in all animals. In contrast, no antibodies were induced when pigs were immunise...

journal_title：Virus research

authors： Denner J,Petersen B,Niemann H

更新日期：2015-10-02 00:00:00

abstract：:Prion diseases or Transmissible Spongiform Encephalopathies (TSEs) are a group of fatal neurodegenerative disorders affecting several mammalian species being Creutzfeldt-Jacob Disease (CJD) the most representative in human beings, scrapie in ovine, Bovine Spongiform Encephalopathy (BSE) in bovine and Chronic Wasting D...

journal_title：Virus research

authors： Fernández-Borges N,Eraña H,Venegas V,Elezgarai SR,Harrathi C,Castilla J

更新日期：2015-09-02 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSE) are a heterogeneous group of neurodegenerative disorders. The common feature of these diseases is the pathological conversion of the normal cellular prion protein (PrP(C)) into a β-structure-rich conformer-termed PrP(Sc). The latter can induce a self-perpetuating process...

journal_title：Virus research

authors： Le NT,Narkiewicz J,Aulić S,Salzano G,Tran HT,Scaini D,Moda F,Giachin G,Legname G

更新日期：2015-09-02 00:00:00

abstract：:The positive sense genomes of members of the genus Flavivirus in the family Flaviviridae are ∼ 11 kb in length and have a 5' type I cap but no 3' poly-A. The 3' and 5' terminal regions contain short conserved sequences that are proposed to be repeated remnants of an ancient sequence. However, the functions of most of ...

journal_title：Virus research

authors： Brinton MA,Basu M

更新日期：2015-08-03 00:00:00

abstract：:Human papillomavirus (HPV) infection leads to aneuploidy, a numerical chromosomal aberration that is caused by dysregulation of chromosomal segregation. We previously found that the E7 proteins of high-risk HPVs, but not of low-risk HPVs, could bind to centromere protein-C (CENP-C). In this study, we first found that ...

journal_title：Virus research

authors： Yaginuma Y,Yoshimoto M,Eguchi A,Tokuda A,Takahashi S

更新日期：2015-07-02 00:00:00

abstract：:Herein we describe the construction of recombinant human rhinoviruses (rHRVs) encoding HIV Gag or Tat by inserting the full length tat gene or regions of the gag gene flanked by sequences encoding the HRV 2A protease cleavage site into the junction between HRV genes encoding structural (P1) and non-structural (P2) pro...

journal_title：Virus research

authors： Tomusange K,Yu W,Suhrbier A,Wijesundara D,Grubor-Bauk B,Gowans EJ

更新日期：2015-05-04 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) is a major disease affecting pigs worldwide and resulting in considerable economic losses. While PRRS is a global phenomenon, the causative viruses PRRSV-1 (first detected in Europe) and PRRSV-2 (isolated in North America) are genetically and biologically distinct. ...

journal_title：Virus research

authors： Salguero FJ,Frossard JP,Rebel JM,Stadejek T,Morgan SB,Graham SP,Steinbach F

更新日期：2015-04-16 00:00:00

abstract：:Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses that infect a wide range of avian and mammalian species, including humans. The emergence of deadly human coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (ME...

journal_title：Virus research

authors： Millet JK,Whittaker GR

更新日期：2015-04-16 00:00:00

abstract：:Marek's disease virus (MDV) is a lymphotropic alphaherpesvirus and causes Marek's disease (MD) in chickens. RLORF4 is an MDV-specific gene located in the repeat long (RL) regions of the genome and is directly involved in attenuation. In this report, we generated recombinant (r)MDVs in which eGFP or mRFP was inserted i...

journal_title：Virus research

authors： Jarosinski KW,Donovan KM,Du G

更新日期：2015-04-02 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) is a widespread pathogen of pigs causing significant economic losses to the swine industry. The expanding diversity of PRRSV strains makes the diagnosis, control and eradication of the disease more and more difficult. In the present study, the authors report ...

journal_title：Virus research

authors： Balka G,Wang X,Olasz F,Bálint Á,Kiss I,Bányai K,Rusvai M,Stadejek T,Marthaler D,Murtaugh MP,Zádori Z

更新日期：2015-03-16 00:00:00

abstract：:The main cellular target for African swine fever virus (ASFV) is the porcine macrophage. However, existing data about the early phases of infection were previously characterized in non-leukocyte cells such as Vero cells. Here, we report that ASFV enters the natural host cell using dynamin-dependent and clathrin-mediat...

journal_title：Virus research

authors： Galindo I,Cuesta-Geijo MA,Hlavova K,Muñoz-Moreno R,Barrado-Gil L,Dominguez J,Alonso C

更新日期：2015-03-16 00:00:00

abstract：:Human metapneumovirus (hMPV) is a major cause of respiratory tract infections in children, elderly and immunocompromised hosts, for which no vaccine or treatment are currently available. Oxidative stress and inflammatory responses represent important pathogenic mechanism(s) of hMPV infection. Here, we explored the pot...

journal_title：Virus research

authors： Komaravelli N,Kelley JP,Garofalo MP,Wu H,Casola A,Kolli D

更新日期：2015-03-16 00:00:00

abstract：:VP28 and VP24 are two major envelope proteins of white spot syndrome virus (WSSV). The direct interaction between VP28 and VP24 has been described in previous studies. In this study, we confirmed this interaction and mapped the interaction domains of VP28 and VP24 by constructing a series of deletion mutants. By co-im...

journal_title：Virus research

authors： Li Z,Chen W,Xu L,Li F,Yang F

更新日期：2015-03-16 00:00:00

abstract：:Viral vectors are important vehicles in vaccine research. Avipoxviruses including fowlpox virus (FPV) play major roles in viral vaccine vector development for the prevention and therapy of human and other veterinary diseases due to their immunomodulatory effects and safety profile. Recently, we analyzed the genomic an...

journal_title：Virus research

authors： Du S,Liu C,Zhu Y,Wang Y,Ren D,Wang M,Tan P,Li X,Tian M,Zhang Y,Li J,Zhao F,Li C,Jin N

更新日期：2015-02-02 00:00:00

abstract：:Dengue virus (DENV) infection associates with renal disorders. Patients with dengue hemorrhagic fever and acute kidney injury have a high mortality rate. Increased levels of cytokines may contribute to the pathogenesis of DENV-induced kidney injury. Currently, molecular mechanisms how DENV induces kidney cell injury h...

journal_title：Virus research

authors： Khunchai S,Junking M,Suttitheptumrong A,Kooptiwut S,Haegeman G,Limjindaporn T,Yenchitsomanus PT

更新日期：2015-02-02 00:00:00

abstract：:MicroRNAs (miRNAs) constitute an important class of non-coding RNA implicated in gene expression regulation. More than 1900 miRNA molecules have been identified in humans and their modulation during viral infection and it is recognized to play a role in latency regulation or in establishing an antiviral state. The liv...

journal_title：Virus research

authors： Escalera-Cueto M,Medina-Martínez I,del Angel RM,Berumen-Campos J,Gutiérrez-Escolano AL,Yocupicio-Monroy M

更新日期：2015-01-22 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in viral infections, especially by modulating the expression of cellular factors essential to viral replication or the host innate immune response to infection. To identify host miRNAs important to controlling porcine reproductive and respiratory syndrome virus (PRRSV) infection...

journal_title：Virus research

authors： Li L,Wei Z,Zhou Y,Gao F,Jiang Y,Yu L,Zheng H,Tong W,Yang S,Zheng H,Shan T,Liu F,Xia T,Tong G

更新日期：2015-01-02 00:00:00

abstract：:Dengue is now hyper-endemic in most parts of south and southeast Asia including India. The northern India particularly national capital New Delhi witnessed major Dengue outbreaks with Dengue virus type 1 (DENV-1) as the dominant serotype since last five years. This study was initiated to decipher the complete genome i...

journal_title：Virus research

authors： Dash PK,Sharma S,Soni M,Agarwal A,Sahni AK,Parida M

更新日期：2015-01-02 00:00:00

abstract：:Rice false smut caused by Ustilaginoidea virens is a destructive disease in many rice-growing areas. Mycoviruses have been described in many fungal species, but there is little information regarding mycoviruses in U. virens. In this study, double-stranded (ds) RNA banding patterns were assessed in 198 wild-type isolat...

journal_title：Virus research

authors： Jiang Y,Zhang T,Luo C,Jiang D,Li G,Li Q,Hsiang T,Huang J

更新日期：2015-01-02 00:00:00

abstract：:In mice Theiler's murine encephalomyelitis virus (TMEV) persists in macrophages that eventually undergo apoptosis. TMEV infection of macrophages in culture induces apoptosis through the intrinsic pathway, restricting virus yields. We show that inhibition of TMEV-induced apoptosis leads to phosphorylation of receptor i...

journal_title：Virus research

authors： Son KN,Lipton HL

更新日期：2015-01-02 00:00:00

abstract：:The highly heterogeneous porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent responsible for an economically important pig disease with the characteristic symptoms of reproductive losses in breeding sows and respiratory illnesses in young piglets. The virus can be broadly divided into th...

journal_title：Virus research

authors： Lu ZH,Archibald AL,Ait-Ali T

更新日期：2014-12-19 00:00:00

abstract：:Coronavirus genome replication is mediated by a multi-subunit protein complex that is comprised of more than a dozen virally encoded and several cellular proteins. Interactions of the viral replicase complex with cis-acting RNA elements located in the 5' and 3'-terminal genome regions ensure the specific replication o...

journal_title：Virus research

authors： Madhugiri R,Fricke M,Marz M,Ziebuhr J

更新日期：2014-12-19 00:00:00

abstract：:Apoptosis is frequently induced to inhibit virus replication during infection of Enterovirus 71 (EV71). On the contrary, anti-apoptotic pathway, such as PI3K/Akt pathway, is simultaneously exploited by EV71 to accomplish the viral life cycle. The relationship by which EV71-induced apoptosis and PI3K/Akt signaling path...

journal_title：Virus research

authors： Zhang H,Li F,Pan Z,Wu Z,Wang Y,Cui Y

更新日期：2014-11-04 00:00:00

abstract：:The compound LPRP-Et-97543 was isolated from Liriope platyphylla roots and was observed to have potential anti-viral effects in HepG2.2.15 cells against hepatitis B virus (HBV). The antiviral mode was further clarified, and the HBV-transfected Huh7 cells were used as the platform. During viral gene expression, LPRP-Et...

journal_title：Virus research

authors： Huang TJ,Tsai YC,Chiang SY,Wang GJ,Kuo YC,Chang YC,Wu YY,Wu YC

更新日期：2014-11-04 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus, is a causative agent of porcine enteric disease characterized by acute watery diarrhea and dehydration in sucking piglet. Similar to other coronaviruses, PEDV spike protein mediates its cell entry by binding to cellular receptors and induc...

journal_title：Virus research

authors： Park JE,Cruz DJ,Shin HJ

更新日期：2014-10-13 00:00:00

abstract：:The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac78 gene is one of the baculovirus core genes. Recent studies showed that ac78 is essential for budded virion (BV) production and the embedding of occlusion-derived virion (ODV) into occlusion body during the AcMNPV life cycle. Here, we report that an ...

journal_title：Virus research

authors： Li SN,Wang JY,Yuan MJ,Yang K

更新日期：2014-10-13 00:00:00

abstract：:Bovine enteroviruses, which belong to the Picornaviridae family, can cause clinical symptoms in cattle and are excreted in feces. In this study, a cytolytic virus was isolated from Madin-Darby bovine kidney (MDBK) cells from fecal samples of bovine with severe diarrhea and hemorrhagic intestinal mucosa that had been o...

journal_title：Virus research

authors： Zhang H,Liu H,Bao J,Guo Y,Peng T,Zhou P,Zhang W,Ma B,Wang J,Gao M

更新日期：2014-10-13 00:00:00

abstract：:JCPyV and BKPyV are common human polyomaviruses that cause lifelong asymptomatic persistent infections in their hosts. In immunosuppressed individuals, increased replication of JCPyV and BKPyV cause significant disease. JCPyV causes a fatal and rapidly progressing demyelinating disease known as progressive multifocal ...

journal_title：Virus research

authors： O'Hara BA,Rupasinghe C,Yatawara A,Gaidos G,Mierke DF,Atwood WJ

更新日期：2014-08-30 00:00:00

abstract：:Mouse Hepatitis Virus (MHV) is a single-stranded positive sense RNA virus with the ability to promote acute and chronic diseases in mice. The MHV spike protein (S) is a major virulence determinant which in addition to binding to cellular receptors to mediate cell entry and facilitate virus spread to adjacent cells by ...

journal_title：Virus research

authors： Kaufman G,Liu P,Leibowitz JL

更新日期：2014-08-30 00:00:00

abstract：:Raccoons (Procyon lotor), which are not native to Japan, have been suspected to transmit various pathogens by frequent intrusion into agricultural and residential areas. To determine influenza A virus seropositivity in raccoons in Japan, we examined a total of 634 raccoons captured in 19 towns (A-S) from 2009 to 2012....

journal_title：Virus research

authors： Yamaguchi E,Sashika M,Fujii K,Kobayashi K,Bui VN,Ogawa H,Imai K

更新日期：2014-08-30 00:00:00

abstract：:Adult T cell leukemia/lymphoma (ATL) is a highly aggressive CD4+/CD25+ T-cell malignancy caused by human T cell lymphotropic virus type 1 (HTLV-1). Previous studies in the MET-1 cell/NOD/SCID mouse model of ATL demonstrated that MET-1 cells are very susceptible to measles virus (MV) oncolytic therapy. To further evalu...

journal_title：Virus research

authors： M Parrula MC,Fernandez SA,Landes K,Huey D,Lairmore M,Niewiesk S

更新日期：2014-08-30 00:00:00

abstract：:This paper summarizes the progress in the search for hantaviruses and hantavirus infections in Africa. After having collected molecular evidence of an indigenous African hantavirus in 2006, an intensive investigation for new hantaviruses has been started in small mammals. Various novel hantaviruses have been molecular...

journal_title：Virus research

authors： Witkowski PT,Klempa B,Ithete NL,Auste B,Mfune JK,Hoveka J,Matthee S,Preiser W,Kruger DH

更新日期：2014-07-17 00:00:00

abstract：:This review focuses on new or improved technologies currently being applied, or likely to be applied in the future, to worldwide research on plant virus epidemiology. Recent technological advances and innovations provide many opportunities to improve understanding of the way diverse types of plant virus epidemics deve...

journal_title：Virus research

authors： Jones RA

更新日期：2014-06-24 00:00:00

abstract：:Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung injury. Here, we showed...

journal_title：Virus research

authors： Liu X,Yang N,Tang J,Liu S,Luo D,Duan Q,Wang X

更新日期：2014-06-24 00:00:00

abstract：:Over the past three decades diseases caused by whitefly-transmitted geminiviruses (begomoviruses) have emerged to be important constraints to the production of solanaceous crops, particularly tomato (Solanum lycopersicum) and peppers (Capsicum spp.), in many tropical and subtropical regions of the world. The most stud...

journal_title：Virus research

authors： Kenyon L,Tsai WS,Shih SL,Lee LM

更新日期：2014-06-24 00:00:00

abstract：:The aim of the present study was to analyze the influence of virus origin, mammalian or mosquito cell-derived, on antiviral susceptibility of DENV-2 to entry inhibitors and the association of this effect with any alteration in the mode of entry into the cell. To this end, ten serial passages of DENV-2 were performed i...

journal_title：Virus research

authors： Acosta EG,Piccini LE,Talarico LB,Castilla V,Damonte EB

更新日期：2014-05-12 00:00:00

abstract：:The disulphide-linked GP2/3/4 spike of equine arteritis virus (EAV) is essential for virus entry. We showed recently that in transfected cells carbohydrates attached adjacent to the signal peptide of GP3 inhibit cleavage. Here we confirm this unique phenomenon in recombinant viruses with disabled glycosylation sites. ...

journal_title：Virus research

authors： Matczuk AK,Veit M

更新日期：2014-04-01 00:00:00